Product Name :
2-Propylglutaric Acid (CAS 32806-62-5)
Synonym :
2-PGA; 2-Propyl-pentanedioic Acid;
Application :
2-Propylglutaric Acid is a metabolite of Valproic Acid
CAS:
32806-62-5
Purity:
Molecular Weight:
174.19
Formula :
C8H14O4
Physical state:
Solid
solubility :
Soluble in Chloroform and Methanol
Shipping Condition :
Store at -20° C
Melting point:
70-72° C
SMILES:
CCCC(CCC(=O)O)C(=O)O
References:
:Disposition of valproic acid in maternal, fetal, and newborn sheep. II: metabolism and renal elimination. | Kumar, S., et al. 2000. Drug Metab Dispos. 28: 857-64. PMID: 10859160The effect of valproic acid on hepatic and plasma levels of 15-F2t-isoprostane in rats. | Tong, V., et al. 2003. Free Radic Biol Med. 34: 1435-46. PMID: 12757854In vitro effects of valproate and valproate metabolites on mitochondrial oxidations. Relevance of CoA sequestration to the observed inhibitions. | Ponchaut, S., et al. 1992. Biochem Pharmacol. 43: 2435-42. PMID: 1610408Influence of chronic administration of valproate on ultrastructure and enzyme content of peroxisomes in rat liver and kidney. Oxidation of valproate by liver peroxisomes. | Ponchaut, S., et al. 1991. Biochem Pharmacol. 41: 1419-28. PMID: 2018550Brain metabolomic profiling of eastern honey bee (Apis cerana) infested with the mite Varroa destructor. | Wu, JL., et al. 2017. PLoS One. 12: e0175573. PMID: 28403242Determination of valproic acid and its metabolites by gas chromatography-mass spectrometry with selected ion monitoring.1-Bromo-3-fluoro-2-methyl-4-nitrobenzene Chemscene | Tatsuhara, T.728034-12-6 Formula , et al. 1987. J Chromatogr. 399: 183-95. PMID: 3116023Capillary gas chromatographic assay for valproic acid and its 2-desaturated metabolite in brain and plasma. | Semmes, RL. and Shen, DD. 1988. J Chromatogr. 432: 185-97. PMID: 3146579Determination of valproic acid and its six metabolites in human serum using LC-MS/MS and application to interaction with carbapenems in epileptic patients.PMID:33580870 | Yang, X., et al. 2023. Biomed Chromatogr. 37: e5572. PMID: 36520520Inhibition of gluconeogenesis by sodium valproate and its metabolites in isolated rat hepatocytes. | Rogiers, V., et al. 1985. Xenobiotica. 15: 759-65. PMID: 3934853Identification of valproic acid metabolites in human serum and urine using hexadeuterated valproic acid and gas chromatographic mass spectrometric analysis. | Acheampong, A., et al. 1983. Biomed Mass Spectrom. 10: 586-95. PMID: 6419788Five doubly unsaturated metabolites of valproic acid in urine and plasma of patients on valproic acid therapy. | Kochen, W., et al. 1984. J Clin Chem Clin Biochem. 22: 309-17. PMID: 6429268Valproic acid and several metabolites: quantitative determination in serum, urine, breast milk and tissues by gas chromatography-mass spectrometry using selected ion monitoring. | Nau, H., et al. 1981. J Chromatogr. 226: 69-78. PMID: 6798056Sodium valproate down-regulates the myristoylated alanine-rich C kinase substrate (MARCKS) in immortalized hippocampal cells: a property of protein kinase C-mediated mood stabilizers. | Watson, DG., et al. 1998. J Pharmacol Exp Ther. 285: 307-16. PMID: 9536026