Herein, we present (E)-selective transfer semihydrogenation of alkynes {based|primarily based} on in situ generated iridium {complex|complicated} from [Ir(COD)Cl]2 and unsymmetrical ferrocene-based phosphine ligand {in the|within the|inside the} presence of formic acid as a hydrogen donor. The catalytic {system|method|program|technique} is distinguished by unprecedented chemoselectivity and exceptional stereoselectivity substantiated by the broad scope of test-ed substrates, {including|such as|which includes|like} {natural|all-natural|organic} {products|goods|items|merchandise|solutions} derivatives. The uniform reaction {conditions|circumstances|situations} {may|might|could|may possibly|may well|may perhaps} be applied to {various|numerous|different|a variety of|several|many} alkynes, owing to a lack of over-reduction. The intriguing {difference|distinction} in catalytic activity {between|in between|among|amongst|involving} unsymmetrical and symmetrical ferrocene-based ligands was attributed to diver-gent coordination and steric hindrance. The presented methodology constitutes a {solution|answer|remedy|resolution|option} {to the|towards the|for the} {common|typical|frequent|widespread|prevalent|popular} limitations {of the|from the|in the|on the|with the|of your} published catalytic systems. 183070-44-2 structure Formula of 14544-47-9 PMID:25955218
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