Tunable aziridinium ylide reactivity: non-covalent interactions {enable|allow} divergent {product|item|solution} outcomes

{Methods|Techniques|Strategies|Approaches|Procedures|Solutions} for {rapid|fast|speedy} preparation of densely functionalized and stereochemically {complex|complicated} N-heterocyclic scaffolds are in demand for exploring {potential|possible|prospective} new bioactive chemical space. This {work|function|perform|operate} describes experimental and computational {studies|research} to…

Novel Pyrazolo[3,4-c]pyridine Antagonists with Nanomolar affinity for A1 / A3 Adenosine Receptors: Binding Kinetics and Exploration of their Binding Profile {Using|Utilizing|Making use of|Employing|Working with|Applying} Mutagenesis Experiments, MD simulations and TI/MD calculations

Drugs targeting the {four|4} adenosine receptor (AR) subtypes can {provide|offer|supply|give|present|deliver} “soft” {treatment|therapy|remedy} of {various|numerous|different|a variety of|several|many} {significant|substantial|considerable|important} {diseases|illnesses|ailments}. Even for the two experimentally resolved AR subtypes the description {of the|from…