The Periodic Table as a Cultural Meme
The Mendeleev periodic table is 150 years old this year. {This article|This short article} {looks|appears} at how it has changed in its history and its wider recognition in human society.…
Olefin Metathesis in Confinement: Towards Covalent Organic Framework Scaffolds for {Increased|Elevated|Improved|Enhanced} Macrocyclization Selectivity
Covalent organic frameworks (COFs) {offer|provide|supply|offer you|present|give} vast structural and chemical diversity enabling a wide and {growing|expanding|developing|increasing} {range|variety} of applications. {While|Whilst|Although|Even though|When|Though} COFs are well-established as homogeneous catalysts, so far, their…
An {efficient|effective} {way to|method to|approach to|strategy to|technique to|solution to} screen inhibitors of energy-coupling {factor|aspect|element|issue} (ECF) transporters in bacteria uptake assay
Herein, we report a novel whole-cell screening assay {using|utilizing|making use of|employing|working with|applying} Lactobacillus casei as model microorganism to {identify|determine|recognize} inhibitors of energy-coupling {factor|aspect|element|issue} (ECF) transporters. This promising and underexplored target…
Galactose Oxidase Enables Modular Assembly of Conjugates from Native Antibodies with {High|Higher} Drug-to-Antibody Ratios
The {potential|possible|prospective} of antibody conjugates with {high|higher} drug loading in anticancer therapy has {recently|lately|not too long ago} been highlighted by the approval of Trastuzumab deruxtecan and Sacituzumab govitecan. These biopharmaceutical…
ChemSpaX: Exploration of Chemical Space by Automated Functionalization of Molecular Scaffold
Exploration {of the|from the|in the|on the|with the|of your} {local|nearby|neighborhood|regional} chemical space of molecular scaffolds by post-functionalization (PF) {is a|is really a|is actually a|can be a|is often a|is usually a} promising…