Uncategorized Archives - Page 24 of 173

Polymer {selection|choice} impacts the pharmaceutical profile of {site|website|web site|internet site|web-site|web page} {specifically|particularly|especially} conjugated Interferon-α2a

Chemexpress February 11, 2025 0 Comments

Conjugation of poly(ethylene glycol) (PEG) to biologics {is a|is really a|is actually a|can be a|is often a|is usually a} {successful|effective|productive|profitable|prosperous|thriving} {strategy|technique|method|approach|tactic} to favorably {impact|influence|effect} the pharmacokinetics and efficacy {of the|from…

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Synthesis, Characterization, and Post-Synthetic Modification of a Micro/Mesoporous Zirconium-Tricarboxylate Metal-Organic Framework: Towards the Addition of Acid Active {Sites|Websites|Web sites|Internet sites|Web-sites|Web pages}

Chemexpress February 11, 2025 0 Comments

Zr-MOFs are characterized by their {high|higher} thermal andchemical stability which {may|might|could|may possibly|may well|may perhaps} facilitate their application in heterogeneouscatalysis. {However|Nevertheless|Nonetheless|Even so|On the other hand|Having said that}, these well-known microporous {materials|supplies|components}…

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Umpolung AlaB Reagents for the Synthesis of Non-Proteogenic Amino Acids, Peptides and Proteins

Chemexpress February 11, 2025 0 Comments

Non-proteogenic amino acids and functionalized peptides are {important|essential|crucial|critical|significant|vital} motifs in {modern|contemporary|modern day} drug discovery and {used|utilized|employed|utilised|applied|made use of} as mechanistic tools in chemical biology. {Here|Right here}, we show that functionalized…

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Amine-Catalyzed Copper-Mediated C–H Sulfonylation of Benzaldehydes {via|by way of|through|by means of} a Transient Imine Directing Group

Chemexpress February 11, 2025 0 Comments

Transient directing groups can {provide|offer|supply|give|present|deliver} a {powerful|potent|effective|strong|highly effective} {means|indicates|implies|signifies|suggests} for C–H functionalization to {install|set up} medicinally {valuable|beneficial|useful|worthwhile|precious|important} motifs {without|with out|without having|with no|devoid of|without the need of} requiring {additional|extra|further|added|more} {steps|actions|measures|methods} for…

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Multi-scale imaging of protein oxidation in mayonnaise

Chemexpress February 11, 2025 0 Comments

In mayonnaise, lipid and protein oxidation are closely {related|associated|connected} {and the|and also the|as well as the|along with the|plus the} interplay {between|in between|among|amongst|involving} them is {critical|crucial|vital|essential|important} for understanding the chemical shelf-life…

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Micellar Composition {Affects|Impacts} Lipid Accretion Kinetics in Molecular Dynamics Simulations

Chemexpress February 11, 2025 0 Comments

Mixed lipid micelles {were|had been|have been} proposed to facilitate the emergence of life {through|via|by means of|by way of} their documented {growth|development} dynamics and catalytic properties. Our {research|study|analysis|investigation} predicted that micellar…

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Syntheses and activities of indol-2-ylidene-ligated ruthenium-based olefin metathesis catalysts

Chemexpress February 10, 2025 0 Comments

{Here|Right here} we report {a new|a brand new} {family|family members|loved ones|household} of indol-2-ylidene (IdY)-ligated Ru-based olefin metathesis catalysts (Ru−IdY) and their X-ray crystal structures which show a {unique|distinctive|special|exclusive|exceptional|one of a…

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Combining structural and bioactivity-based fingerprints improves prediction {performance|overall performance|efficiency|functionality} and scaffold-hopping capability

Chemexpress February 10, 2025 0 Comments

This study aims at {improving|enhancing} upon existingactivity predictions {methods|techniques|strategies|approaches|procedures|solutions} by augmenting chemical structure fingerprints withbio-activity {based|primarily based} fingerprints derived from high-throughput screening (HTS){data|information} (HTSFPs). The HTSFPs {were|had been|have been} generated…

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Based-Catalyzed Stereoselective Thiosulfonylation of Ynones

Chemexpress February 10, 2025 0 Comments

{The first|The very first|The initial} catalytic vicinal thiosulfonylation of ynones has been {developed|created}. {Under|Below|Beneath} the catalysis of 1-10 mol% Cs2CO3, {various|numerous|different|a variety of|several|many} thiosulfonates underwent Michael addition/nucleophilic substitution tandem reaction…

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{Fast|Quick|Quickly|Rapidly|Rapid|Speedy} and {accurate|correct|precise} quantum mechanical modeling of {large|big|huge|massive|substantial|significant} molecular systems {using|utilizing|making use of|employing|working with|applying} {small|little|tiny|modest|smaller|compact} basis set Hartree–Fock {methods|techniques|strategies|approaches|procedures|solutions} corrected with atom-centered potentials

Chemexpress February 10, 2025 0 Comments

There has been {significant|substantial|considerable|important} interest in {developing|creating|building|establishing} {fast|quick|quickly|rapidly|rapid|speedy} and {accurate|correct|precise} quantum mechanical {methods|techniques|strategies|approaches|procedures|solutions} for modeling {large|big|huge|massive|substantial|significant} molecular systems. {In this|Within this} {work|function|perform|operate}, by {utilizing|using} a machine-learning regression {technique|method|approach|strategy}, {we have|we’ve|we’ve…

Polymer {selection|choice} impacts the pharmaceutical profile of {site|website|web site|internet site|web-site|web page} {specifically|particularly|especially} conjugated Interferon-α2a

Synthesis, Characterization, and Post-Synthetic Modification of a Micro/Mesoporous Zirconium-Tricarboxylate Metal-Organic Framework: Towards the Addition of Acid Active {Sites|Websites|Web sites|Internet sites|Web-sites|Web pages}

Umpolung AlaB Reagents for the Synthesis of Non-Proteogenic Amino Acids, Peptides and Proteins

Amine-Catalyzed Copper-Mediated C–H Sulfonylation of Benzaldehydes {via|by way of|through|by means of} a Transient Imine Directing Group

Multi-scale imaging of protein oxidation in mayonnaise

Micellar Composition {Affects|Impacts} Lipid Accretion Kinetics in Molecular Dynamics Simulations

Syntheses and activities of indol-2-ylidene-ligated ruthenium-based olefin metathesis catalysts

Combining structural and bioactivity-based fingerprints improves prediction {performance|overall performance|efficiency|functionality} and scaffold-hopping capability

Based-Catalyzed Stereoselective Thiosulfonylation of Ynones

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