Computational {Design|Style|Design and style}, Synthesis and Photochemistry of Cy7-PPG, an {Efficient|Effective} NIR-activated Photolabile {Protecting|Guarding|Defending|Safeguarding} Group for Therapeutic Applications

Photolabile {Protecting|Guarding|Defending|Safeguarding} Groups (PPGs) are chemical tools {used|utilized|employed|utilised|applied|made use of} in photopharmacology for the oxygen-independent release of bioactive payloads, enabling spatiotemporal activation of their bioactivity. {However|Nevertheless|Nonetheless|Even so|On the other hand|Having…

Regioselective access to orthogonal Diels-Alder C60 bis-adducts and tris-heteroadducts {via|by way of|through|by means of} avant-garde supramolecular mask {strategy|technique|method|approach|tactic}

The regioselective poly-functionalization of {highly|extremely|very|hugely} symmetric spherical Ih-C60 is {extremely|very|incredibly|really|particularly|exceptionally} {challenging|difficult} and {usually|generally|typically|normally|commonly|ordinarily} {leads to|results in} the formation of regio-isomeric mixtures not amenable for HPLC purification. {Recently|Lately|Not too long ago},…

{Learning|Studying|Understanding|Finding out|Mastering} relationships {between|in between|among|amongst|involving} chemical and physical stability for drug {development|improvement}

Chemical and physical stabilities are two {key|important|crucial|essential} {features|attributes|functions|characteristics|capabilities|options} {considered|regarded as|deemed|regarded|viewed as|thought of} in pharmaceutical {development|improvement}. Chemical stability is {typically|usually|normally|generally|commonly|ordinarily} reported as a {combination|mixture} of potency and degradation {product|item|solution}. For peptide…