Stereochemical engineering of a peptide macrocycle allosteric inhibitor of phospho-Akt2 controls cell penetration by fine-tuning macrocycle-cell membrane interactions
We report the {development|improvement} of a cell-penetrant cyclic loop biligand that selectively binds, in vitro, {to the|towards the|for the} phosphorylated Ser474 {site|website|web site|internet site|web-site|web page} of Protein Kinase B (p-Akt2)…