Metal-organic frameworks (MOFs) have been used to improve vaccine formulations by stabilizing proteins and protecting them against thermal degradation. This has led to increased2immunogenicity of these proteinaceous therapeutics. In this…
Many essential processes occur at soft interfaces, from chemical reactions on aqueous aerosols in the atmosphere to biochemical recognition and binding at the surface of cell membranes. The spatial arrangement…
Dextran-based hydrogels are promising therapeutic materials for drug delivery, tissue regeneration devices, and cell therapy vectors, due to their high biocompatibility, along with their ability to protect and release active…
In vitro gliding assay is a well-established assay for determining the activity of protein motors, such as actin-associated myosins and microtubule-associated kinesins and dyneins. In one of the conventional methods,…
{An effective|An efficient} nickel-catalyzed cross coupling of umpolung carbonyls and alkyl halides was {developed|created}. Contrary to classical alkylation {techniques|methods|strategies|tactics|approaches|procedures}, this reaction utilizes umpolung carbonyls {as the|because the} environmentally benign alkyl…
Density functional theory (DFT) is a ubiquitous first-principles method, but the approximate nature of the exchange-correlation functional poses an inherent limitation for the accuracy of various computed properties. In this…
Machine learning methods have garnered much attention and use in computational catalysis. Previous studies have demonstrated rapid and accurate prediction of a variety of catalytic properties as well as the…
Electrochemical quartz crystal microbalance (EQCM) is a powerful technique to screen the gravimetric response of electrochemical electrodes. In this study, a straightforward mathematical method is proposed for extracting and deconvoluting…
Proteolysis targeting chimeras (PROTACs) are bifunctional molecules that induce ubiquitination and subsequent degradation of proteins via formation of ternary complexes between an E3 ubiquitin ligase and a target protein. Rational…
Passive permeability of a drug-like molecule is a critical assay early in a drug discovery campaign that informs a medicinal chemist how well a compound can traverse biological membranes, such…