A modular {approach|method|strategy} to prepare tri- and tetracyclic carbazoles by a sequential heteroannulation is described. {First|Initial|Very first|1st|Initially}, op-timization of a Pd-catalyzed Buchwald-Hartwig amination followed by C/N-arylation {in a|inside a|within a}…
Nickel(0) catalysts of N-heterocyclic carbenes (NHCs) {that are|which are|which can be|which might be|that happen to be} stabilized by electronic deficient alkenes possess desirable properties of air tolerance and ease of…
Determination {of the|from the|in the|on the|with the|of your} atomic structure of {solid|strong} surfaces {is a|is really a|is actually a|can be a|is often a|is usually a} challenge {that has|which has} resisted…
Computational {studies|research} of {large|big|huge|massive|substantial|significant} molecular systems are {often|frequently|usually|typically|generally|normally} hindered by resource constraints, {such as|like|including|for example|for instance|which include} the {available|accessible|obtainable|offered|readily available|out there} computational time. A {common|typical|frequent|widespread|prevalent|popular} {approach|method|strategy} to {reduce|decrease|minimize|lessen|lower|cut down} the…
Prenylation plays {an important|an essential|a crucial|a vital} {role|function|part} in diversifying structure and function of secondary metabolites. {Although|Even though|Though|Despite the fact that|While} {several|a number of|numerous|many|various|quite a few} cyanobactin prenyltransferases {have been|happen…