Heterologous Biosynthesis and Genomics-Driven Derivatization of Fungal Bioactive Sesterterpenoid Variecolin
The biosynthetic gene cluster of fungal bioactive sesterterpenoids, variecolin (1) and variecolactone ({2|two}), was identified in Aspergillus aculeatus ATCC 16872. Heterologous production of 1 and {2|two} was {achieved|accomplished} in Aspergillus…