Product Name :
2-Fluoro-2′-deoxyadenosine (CAS 21679-12-9)
Synonym :
(9-(2-Deoxy-b-D-ribofuranosyl)-2-fluoroadenine
Application :
CAS:
21679-12-9
Purity:
Molecular Weight:
269.23
Formula :
C10H12FN5O3
Physical state:
Solid
solubility :
Shipping Condition :
Store at -20° C
Melting point:
SMILES:
C1[C@@H]([C@H](O[C@H]1N2C=NC3=C2N=C(N=C3N)F)CO)O
References:
:Antitumor activity of 2-fluoro-2′-deoxyadenosine against tumors that express Escherichia coli purine nucleoside phosphorylase. | Parker, WB., et al. 2003. Cancer Gene Ther. 10: 23-9. PMID: 12489025A human biotin acceptor domain allows site-specific conjugation of an enzyme to an antibody-avidin fusion protein for targeted drug delivery. | Asai, T., et al. 2005. Biomol Eng. 21: 145-55. PMID: 15748688Study of a hammerhead ribozyme containing 2′-modified adenosine residues. | Olsen, DB., et al. 1991. Biochemistry. 30: 9735-41. PMID: 1911762Structure of a mutant human purine nucleoside phosphorylase with the prodrug, 2-fluoro-2′-deoxyadenosine and the cytotoxic drug, 2-fluoroadenine. | Afshar, S., et al. 2009. Protein Sci. 18: 1107-14. PMID: 19388075Atomic substitution reveals the structural basis for substrate adenine recognition and removal by adenine DNA glycosylase. | Lee, S. and Verdine, GL. 2009. Proc Natl Acad Sci U S A. 106: 18497-502. PMID: 19841264Susceptibility in vitro of clinically metronidazole-resistant Trichomonas vaginalis to nitazoxanide, toyocamycin, and 2-fluoro-2′-deoxyadenosine. | Wright, JM., et al. 2010. Parasitol Res. 107: 847-53. PMID: 20532912Structural and kinetic studies of Schistosoma mansoni adenylate kinases. | Marques, Ide A., et al. 2012. Mol Biochem Parasitol. 185: 157-60. PMID: 22841753Synthesis, solution and crystal structure of the coenzyme B(12) analogue Co( beta )-2′-fluoro-2′,5′-dideoxyadenosylcobalamin. | Hunger, M., et al. 2015. J Inorg Biochem. 148: 62-8. PMID: 25726330Characterization of 2-Fluoro-2′-deoxyadenosine in Duplex, G-Quadruplex and i-Motif.Buy2,2,6,6-Tetramethylmorpholine | Hirashima, S.Azido-PEG9-amine Data Sheet , et al.PMID:33648421 2022. Chembiochem. 23: e202200222. PMID: 35438834Nitro-Activated Nucleobase Exchange in the Synthesis of 2′-Fluoro-2′-Deoxyribonucleosides. | Gong, Y., et al. 2022. J Org Chem. 87: 9330-9342. PMID: 35759615Isolation and Characterization of Engineered Nucleoside Deoxyribosyltransferase with Enhanced Activity Toward 2′-Fluoro-2′-Deoxynucleoside. | Yoo, YJ., et al. 2022. J Microbiol Biotechnol. 32: 1041-1046. PMID: 35791073Pathways of nucleotide metabolism in Schistosoma mansoni–VII. Inhibition of adenine and guanine nucleotide synthesis by purine analogs in intact worms. | Senft, AW. and Crabtree, GW. 1977. Biochem Pharmacol. 26: 1847-55. PMID: 410421Multinuclear magnetic resonance studies of monomers and dimers containing 2′-fluoro-2′-deoxyadenosine. | Cheng, DM., et al. 1983. Biopolymers. 22: 1427-44. PMID: 6223669Synthesis and characterization of the dinucleoside monophosphates containing 2′-fluoro-2′-deoxyadenosine. | Uesugi, S., et al. 1981. Biochemistry. 20: 3056-62. PMID: 6972783Deoxyguanosine-resistant leukemia L1210 cells. Loss of specific deoxyribonucleoside kinase activity. | Cory, AH., et al. 1993. J Biol Chem. 268: 405-9. PMID: 8380161