Product Name :
VPAC2R Rabbit Polyclonal Antibody
Predicted band size :
Observed band size :
Synonyms:
Helodermin-preferring VIP receptor antibody PACAP type III receptor antibody PACAP-R-3 antibody PACAP-R3 antibody Pituitary adenylate cyclase-activating polypeptide type III receptor antibody Vasoactive intestinal polypeptide receptor 2 antibody VIP Receptor 2 antibody VIP-R-2 antibody Vipr2 antibody VIPR2_HUMAN antibody 展开
Function :
There are two known receptors for the vasoactive intestinal peptide (VIP) termed VPAC1 and VPAC2. These receptors bind both VIP and pituitary adenylate cyclase-activating polypeptide (PACAP) to some degree. Both receptors are members of the 7 transmembrane G protein-coupled receptor family. VPAC1 is distributed widely in the CNS, liver, lung, intestine and T-lymphocytes. VPAC2 is found in the CNS, pancreas, skeletal muscle, heart, kidney, adipose tissue, testis, and stomach. Vasoactive intestinal peptide (VIP) and pituitary adenylate cyclase-activating peptide (PACAP) receptors are activated by the endogenous peptides VIP, PACAP-38, PACAP-27, peptide histidine isoleucineamide (PHI), peptide histidine methionineamide (PHM) and peptide histidine valine (PHV). “PACAP type II receptors” (VPAC1 and VPAC2 receptors) display comparable affinity for PACAP and VIP, whereas PACAP-27 and PACAP-38 are >100 fold more potent than VIP as agonists of most isoforms of the PAC1 receptor.
Antibody Type:
Rabbit Polyclonal Antibody
Immunogen :
KLH conjugated synthetic peptide derived from rat VIP receptor II 81-170/437
Species reactivity:
Human, Mouse, Rat, Rabbit
Verify application:
WB, ELISA, IHC-P, FC, IF
Coupling :
unconjugated
Clone number:
RRID:
Form :
Liquid
Concentration :
1ug/ul
Storage instructions:
Store at -20℃ for one year.1380500-86-6 Data Sheet Avoid repeated freeze/thaw cycles.4-Bromo-3-fluoropicolinaldehyde In stock The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20℃.PMID:33678514 When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4℃.
Storage buffer solution:
0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
Subtype:
IgG
Purification method :
Protein A affinity purified.
ELTSA :
Molecular weight :
48 KDa
Positive control :
Expressed in CD4+ T-cells, but not in CD8+ T-cells. Expressed in the T-cell lines Jurkat, PEER, MOLT-4, HSB, YT and Tsup-1, but not in the T-cell lines HARRIS and HUT 78.