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Int. J. Mol. Sci. 2013, 14, 9883-9892; doi:10.3390/ijmsOPEN ACCESSInternational Journal ofMolecular SciencesISSN 1422-0067 mdpi/journal/ijms ReviewRab27 GTPases Distribute Extracellular Nanomaps for Invasive Development and Metastasis: Implications for Prognosis and TreatmentAn Hendrix * and Olivier De Wever Laboratory of Experimental Cancer Investigation, Division of Radiation Oncology and Experimental Cancer Study, Ghent University Hospital, De Pintelaan 185, 9000 Ghent, Belgium; E-Mail: [email protected] * Author to whom correspondence need to be addressed; E-Mail: [email protected]; Tel.: +32-9-332-3008; Fax: +32-9-332-4991. Received: 13 April 2013; in revised form: 19 April 2013 / Accepted: 3 May perhaps 2013 / Published: ten MayAbstract: The Rab27 household of modest GTPases regulates exocytosis of distinct vesicle sorts like multivesicular endosomes, which final results in the release of e.