Product Name :
RSK2 Recombinant Rabbit Monoclonal Antibody [JE63-19]
Predicted band size :
84 kDa
Observed band size :
70 kDa
Synonyms:
90 kDa ribosomal protein S6 kinase 3 antibody CLS antibody HU 3 antibody HU2 antibody HU3 antibody Insulin stimulated protein kinase 1 antibody Insulin-stimulated protein kinase 1 antibody ISPK-1 antibody ISPK1 antibody KS6A3_HUMAN antibody 展开
Function :
Serine/threonine-protein kinase that acts downstream of ERK (MAPK1/ERK2 and MAPK3/ERK1) signaling and mediates mitogenic and stress-induced activation of the transcription factors CREB1, ETV1/ER81 and NR4A1/NUR77, regulates translation through RPS6 and EIF4B phosphorylation, and mediates cellular proliferation, survival, and differentiation by modulating mTOR signaling and repressing pro-apoptotic function of BAD and DAPK1.BuyP(t-Bu)3 Pd G2 In fibroblast, is required for EGF-stimulated phosphorylation of CREB1 and histone H3 at ‘Ser-10’, which results in the subsequent transcriptional activation of several immediate-early genes. In response to mitogenic stimulation (EGF and PMA), phosphorylates and activates NR4A1/NUR77 and ETV1/ER81 transcription factors and the cofactor CREBBP.
Antibody Type:
Recombinant Rabbit monoclonal Antibody
Immunogen :
Synthetic peptide within human RSK2 aa 661-710/740.2,4-Bis(trifluoromethyl)benzaldehyde site
Species reactivity:
Human, Mouse, Rat
Verify application:
WB, IHC-P, FC
Coupling :
unconjugated
Clone number:
JE63-19
RRID:
AB_3072157
Form :
Liquid
Concentration :
1ug/ul
Storage instructions:
Store at +4℃ after thawing.PMID:33455520 Aliquot store at -20℃. Avoid repeated freeze / thaw cycles.
Storage buffer solution:
1*TBS (pH7.4), 0.05% BSA, 40% Glycerol. Preservative: 0.05% Sodium Azide.
Subtype:
IgG
Purification method :
Protein A affinity purified.
ELTSA :
Molecular weight :
Predicted band size: 84 kDa
Positive control :
NIH/3T3 cell lysate, MCF-7 cell lysate, rat lung tissue lysates, human tonsils tissue, human liver carcinoma tissue, human colon carcinoma tissue, human skin tissue, human prostate tissue, human breast tissue, human breast carcinoma tissue, human pancreas tissue, mouse brain tissue, HepG2.