Product Name :
Phospho-Rb (S780) Recombinant Rabbit Monoclonal Antibody [JE44-61]
Predicted band size :
106 kDa
Observed band size :
106 kDa
Synonyms:
Exon 17 tumor GOS561 substitution mutation causes premature stop antibody GOS563 exon 17 substitution mutation causes premature stop antibody OSRC antibody Osteosarcoma antibody p105-Rb antibody P105RB antibody PP105 antibody pp110 antibody PPP1R130 antibody pRb antibody 展开
Function :
The retinoblastoma protein (protein name abbreviated Rb; gene name abbreviated Rb, RB or RB1) is a tumor suppressor protein that is dysfunctional in several major cancers.1228875-16-8 Chemical name One function of pRb is to prevent excessive cell growth by inhibiting cell cycle progression until a cell is ready to divide. When the cell is ready to divide, pRb is phosphorylated, inactivating it, and the cell cycle is allowed to progress. It is also a recruiter of several chromatin remodeling enzymes such as methylases and acetylases. pRb belongs to the pocket protein family, whose members have a pocket for the functional binding of other proteins. Should an oncogenic protein, such as those produced by cells infected by high-risk types of human papillomavirus, bind and inactivate pRb, this can lead to cancer.Vanadium(IV)bis(acetylacetonato)oxide web The RB gene may have been responsible for the evolution of multicellularity in several lineages of life including animals.
Antibody Type:
Recombinant Rabbit monoclonal Antibody
Immunogen :
Synthetic phosphopeptide corresponding to resudues surrounding Ser780 of human Rb protein.PMID:33616462
Species reactivity:
Human, Mouse, Rat
Verify application:
WB
Coupling :
unconjugated
Clone number:
JE44-61
RRID:
AB_3072629
Form :
Liquid
Concentration :
1ug/ul
Storage instructions:
Store at +4℃ after thawing. Aliquot store at -20℃. Avoid repeated freeze / thaw cycles.
Storage buffer solution:
1*TBS (pH7.4), 0.05% BSA, 40% Glycerol. Preservative: 0.05% Sodium Azide.
Subtype:
IgG
Purification method :
Protein A affinity purified.
ELTSA :
Molecular weight :
Predicted band size: 106 kDa
Positive control :
Jurkat serum starved for 24 hours then 10% FBS incubated for 20 hours whole cell lysate.