Product Name :
PLCG2 Rabbit Polyclonal Antibody
Predicted band size :
Observed band size :
Synonyms:
1 phosphatidylinositol 4 5 bisphosphate phosphodiesterase gamma 2 antibody 1-phosphatidylinositol-4 antibody 5-bisphosphate phosphodiesterase gamma-2 antibody EC 3.1.4.11 antibody Phosphoinositide phospholipase C antibody Phosphoinositide phospholipase C-gamma-2 antibody Phospholipase C gamma 2 antibody Phospholipase C, gamma 2 (phosphatidylinositol specific) antibody Phospholipase C-gamma-2 antibody Phospholipase C-IV antibody 展开
Function :
Phosphoinositide-specific phospholipase C (PLC) plays a critical role in the initiation of receptor mediated signal transduction through the generation of the two second messengers, inositol 1,4,5-triphosphate and diacylglycerol from phosphatidylinositol 4,5-bisphosphate.There are many mammalian PLC isozymes, including PLC β1, PLC β2, PLC β3, PLC β4, PLC γ1, PLC γ2, PLC δ1, PLC δ2 and PLC e. After stimulation of the collagen receptor glycoprotein VI in human platelets, PLC γ2 associates with several tyrosine-phosphorylated proteins (Syk, SLP-76, Lyn, linker for activation of T cells (LAT) and the FcR γ chain), which bind to its C-terminal SH2 domain. PLC γ1 associates with Syk in B cells, but PLC γ2 does not associate with Syk in platelets. The C-terminal SH2 domain is involved in the regulation of PLC γ2. In addition, Btk can induce PLC γ2 tyrosine phosphorylation and initiate calcium moblization in CD72-stimulated B lymphocytes.
Antibody Type:
Rabbit Polyclonal Antibody
Immunogen :
Synthetic peptide within human PLCG2 aa 1200-1265.
Species reactivity:
Human
Verify application:
WB, IF-Cell, IHC-P, FC
Coupling :
unconjugated
Clone number:
RRID:
AB_3073397
Form :
Liquid
Concentration :
1ug/ul
Storage instructions:
Store at +4℃ after thawing.197632-76-1 manufacturer Aliquot store at -20℃.2-Ethynyl-1,1′-biphenyl structure Avoid repeated freeze / thaw cycles.PMID:33430676
Storage buffer solution:
1*TBS (pH7.4), 0.2% BSA, 50% Glycerol. Preservative: 0.05% Sodium Azide.
Subtype:
IgG
Purification method :
Immunogen affinity purified.
ELTSA :
Molecular weight :
148 kDa
Positive control :
Raji cell lysates, AGS, human tonsil tissue, Daudi.