Palladium-catalyzed unprecedented atroposelective hydrophosphination of sterically hindered internal alkynes with secondary phosphines has been realized, affording C-N axially chiral trisubstituted olefins (vinylphosphines) in {excellent|superb|outstanding|exceptional|great|fantastic} regioselectivity, (E)-selectivity, and enantioselectivity. The axial…
Computer-aided synthesis {planning|preparing|organizing|arranging} (CASP) tools can propose retrosynthetic pathways and forward reaction {conditions|circumstances|situations} for the synthesis of organic compounds, {but the|however the} {limited|restricted} availability of context-specific {data|information} {currently|presently|at present|at the…
Exploration {of the|from the|in the|on the|with the|of your} zwitterionic {property|home|house} of sulfur ylides has {long|lengthy|extended} been {known|recognized|identified} as a {flexible|versatile} {strategy|technique|method|approach|tactic} {in a|inside a|within a} wide {range of|selection of|array of}…
Hydration {is a|is really a|is actually a|can be a|is often a|is usually a} {key|important|crucial|essential} player in protein-ligand association. No computational {method|technique|approach|strategy|system|process} for modeling hydration has so far {consistently|regularly} {improved|enhanced} the…
Arene semi-reduction remains a challenge when {multiple|numerous|several|a number of|many|various} re-ductively labile functional groups are present or when {using|utilizing|making use of|employing|working with|applying} heteroarene substrates. {Conventional|Standard|Traditional} chemical {and even|as well as|and also|and…