In vitro gliding assay is a well-established assay for determining the activity of protein motors, such as actin-associated myosins and microtubule-associated kinesins and dyneins. In one of the conventional methods,…
{An effective|An efficient} nickel-catalyzed cross coupling of umpolung carbonyls and alkyl halides was {developed|created}. Contrary to classical alkylation {techniques|methods|strategies|tactics|approaches|procedures}, this reaction utilizes umpolung carbonyls {as the|because the} environmentally benign alkyl…
Density functional theory (DFT) is a ubiquitous first-principles method, but the approximate nature of the exchange-correlation functional poses an inherent limitation for the accuracy of various computed properties. In this…
Machine learning methods have garnered much attention and use in computational catalysis. Previous studies have demonstrated rapid and accurate prediction of a variety of catalytic properties as well as the…
Proteolysis targeting chimeras (PROTACs) are bifunctional molecules that induce ubiquitination and subsequent degradation of proteins via formation of ternary complexes between an E3 ubiquitin ligase and a target protein. Rational…